logo

Cisplatin incorporating polymeric micelles NC 6004 can

If you want to confirm some technical details before you order,
just need to send a message or e-mail: [email protected].
Then our professional sales staff will contact you within 2 hours.

Effect of combined treatment with the epirubicin .

Effect of combined treatment with the epirubicin-incorporating micelles (NC-6300) and 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016) on a human gastric cancer model.

NC-6004, a novel cisplatin nanoparticle, in combination .

NC-6004 is a cisplatin nanoparticle developed using a cutting-edge micelle nanotechnology. Cisplatin is encapsulated into approximately 30 nm size polymeric micelles through the polymer-metal complex formation between polyethylene glycol poly (glutamic acid) block copolymers (PEG-P(Glu)) [1].

A Phase I clinical study of cisplatin-incorporated .

On the basis of preclinical studies of NC-6004, a cisplatin-incorporated micellar formulation, we hypothesised that NC-6004 could show lower toxicity than cisplatin and show greater anti-tumour activity in phase I study. The trial was an open-label, dose-escalating, phase I study conducted at two ...

Cisplatin-incorporating polymeric micelles (NC-6004) can .

Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats H Uchino1, Y Matsumura*,1, T Negishi1, F Koizumi1, T Hayashi2, T Honda3, N ...

Preclinical Evaluation of Intravesical Cisplatin .

Our studies showed that more than 2 μg/mL of cisplatin can be detected in plasma within 1 hour after intravesical administration of CDDP solution to mice, supporting the hypersensitivity observed with intravesical CDDP therapy in humans. ... Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of ...

Overcoming tumor resistance to cisplatin by cationic lipid .

Read "Overcoming tumor resistance to cisplatin by cationic lipid-assisted prodrug nanoparticles, Biomaterials" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Development of polymeric micelles for targeting .

In this article, we aim to explain the rationale of designing polymeric micelles for targeting intractable cancers such as pancreatic cancer, glioblastoma, and metastases. Also, we review recent progress in clinical studies on polymeric micelles incorporating anticancer drugs.

Micellization of cisplatin (NC-6004) reduces its .

Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs. ... In this study, we evaluated the ototoxicity of CDDP-incorporating polymeric micelles (NC-6004) in guinea pigs in comparison with that of cisplatin. Their auditory brainstem responses (ABRs) to 2, 6, 12, 20, and 30 kHz sound stimulation were measured before and 5 ...

(PDF) Cisplatin-incorporating polymeric micelles (NC-6004 .

In spite of the clinical usefulness of cisplatin (CDDP), there are many occasions in which it is difficult to continue the administration of CDDP due to its nephrotoxicity and neurotoxicity. ... We examined the incorporation of CDDP into polymeric . Skip to main content ... Cisplatin-incorporating polymeric micelles (NC-6004) can reduce ...

(PDF) Uptake of CDDP-containing polymeric micelles by .

CDDP and cisplatin micelles with micrometer resolution. 12. Uchino H, et al (2005) Cisplatin-incorporating polymeric Information on cytotoxicity when cancer cells are treated micelles (NC-6004) can reduce nephrotoxicity and neurotox- icity of cisplatin in rats.

Cisplatin-incorporating polymeric micelles (NC-6004) can .

Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats Skip to main content Thank you for visiting nature.com.

Polymeric Micellar Delivery Systems in Oncolo

Polymeric Micellar Delivery Systems in Oncology Yasuhiro Matsumura ... The size of the micelles can be controlled within the diameter range of 20–100 nm, to ensure that the micelles do not pass through normal ... NC-6004, CISPLATIN-INCORPORATING MICELLAR NANOPARTICLE BACKGROUND Cisplatin [cis-dichlorodiammineplatinum (II): CDDP] is a

US182377A - Improvement in sugar-mills - Google Paten

US182377A US182377DA US182377A US 182377 A US182377 A US 182377A US 182377D A US182377D A US 182377DA US 182377 A US182377 A US 182377A Authority US United States Prior art keywords mills sugar improvement Prior art date 1876-09-19 Legal status (The legal status is an assumption and is not a legal conclusion.

Factors affecting toxicity and efficacy of polymeric .

Factors affecting toxicity and efficacy of polymeric nanomedicines Factors affecting toxicity and efficacy of polymeric nanomedicines Igarashi, Eiki 2008-05-15 00:00:00 Nanomedicine is the application of nanotechnology to medicine. The purpose of this article is to review common characteristics of polymeric nanomedicines with respect to passive targeting.

Polymeric micelles for targeted tumor therapy of platinum .

A breakthrough in these drawbacks could be achieved by using polymeric micelles, i.e. nanoassemblies having a drug loaded core and a protective hydrophilic shell, incorporating platinum drugs for tumor-targeted delivery.Areas covered: The development of cisplatin- (NC-6004) and DACHPt-loaded micelles (NC-4016) has been reviewed, particularly ...

Clinical development of anticancer agents incorporating .

Clinical development of anticancer agents incorporating micelles in oncological treatment ... Uchino H, Matsumura Y, Negishi T, et al. Cisplatin-Incorporating Polymeric Micelles (NC-6004) Can Reduce Nephrotoxicity and Neurotoxicity of Cisplatin in Rats. ... Eatock.M,Pearson.DG,Ottley.CJ, Matsumura.Y, Kataoka.K, and Nishiya.T. A phase I clinical ...

NC-6004 Phase I study in combination with gemcitabine for .

NC-6004 is a novel micellar nanoparticle product of cisplatin, approximately 30 nm in diameter, obtained by cross-linking with a polyethylene … NC-6004 Phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis | springermedizin.de

Polymeric micelles from poly(ethylene glycol)–poly(amino .

2003 Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice. ... 2006 Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based ... et al. 2005 Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in ...

NAVER Academic > Polymeric micelles – a new generation .

Polymeric micelles are considerably more stable than surfactant micelles and can solubilize substantial amounts of hydrophobic compounds in their inner core. Due to ...